Surface Modification of Hydroxyapatite Nanoparticles using Heparin: Improvement of their Colloidal Stability and Dispersion in Biocomposites

The successful function of a composite-based biomaterial depends in part upon good dispersion and distribution of fillers in polymeric matrix [1]. For a solvent-casting method,distribution of fillers is highly affected by the colloidal stability of the filler in the initial polymeric solution. Although someresearchers have studied the effect of some reagents on the colloidal stability of hydroxyapatite (HAp) nanoparticles, now the type and degree of the reagent remains a matter of concern[2]. In the present study, the effect of heparin (HEP) on the colloidal stability of HAp nanoparticles was investigated.