Theoretical Study on the Structural properties of polyacrylic acid-doxorubicin

In experimental studies carried out by some other researchers, it has been illustrated that amphiphatic block copolymers selfassemble into polymeric micelles in aqueous solution, and potentially can be used as parenteral drug delivery systems. Also, polymer–drug conjugation is one of the other majorstrategies for drug modifications, which manipulates therapeutic agents at molecular level to increase their solubility, permeability and stability, and thus biologicalactivity. Since the early 1980s, polycomplexes have been used for delivery of drugs into living cells. In particular, anioniccarriers such as polyaspartate; polyglutamate; and block ionomers of aspartate, benzyl aspartate, and benzyl glutamate15 with poly(ethylene oxide) demonstrated goodpotential for targeting doxorubicin (DOX), an antitumor drug, into cells and tissues. The therapeutic effect of DOX wassignificantly improved upon binding to polyanions. For this reason, we focused on complexes of DOX with poly (acrylic acid) (PAA).