Synthesis of porous hollow microsphere through suspension polymerization

Microspheres are spherical particles in the size range of about 1micron to 2000micron. The porous and hollow microspheres are more widely used because they can be used as toners, inks,cosmetics, coatings, carrier for drug delivery, ultrasound contrast agents in medical applications, chromatographicpacking, and sound damping and absorption materials.[1,4] Porous hollow microspheres composed of well-defined porous shell which appropriate as carrier in drug delivery system. Microspheres usually are synthesized via suspension polymerization which monomer phase is dispersed intoaqueous phase to form droplets upon agitation and each droplet act as micro reactor which contain bulk polymerization [2]. In this study poly methyl methacrylate (PMMA) was used as linear polymer and ethylene glycol di methacrylate (EGDMA) was used as crosslinker monomer which throughpolymerization form interpenetrating polymer network (IPN) and precipitated polymer on interfacial layer of two phasesform microsphere shell