Investigating of Mixing Uniformity for Drug Filled Silicone Rubber Matrix by Image Analysis

There is a general tendency toward development of long acting implantable drug delivery systems. Non-biodegradable types of such devices can be based on silicone rubber (SR).Mixing uniformity of active agents loaded, in both distribution and dispersion level, directly affects drug release profileincluding phases, amount released per time, and release rate. Here, the effects of varying concentrations of silicone oil on degree of mixing of two steroids blended in a SR matrix is evaluated by analysis of scanning electron micrographs