Preparation of acrylamide grafted carboxymethyl starch and their use as drug carrier

Natural polymers have potential pharmaceutical applications because of their low toxicity, biocompatibility, and excellent biodegradability. Starch is the most abundant, renewablebiopolymer, which is very promising raw material, available at low cost for preparing of various functional polymers. Carboxymethyl starch (CMS) widely used in pharmaceuticals; however, it may need to be further modified for some special applications1. Among diverse approaches that are possible for modifying polysaccharides, grafting of synthetic polymer is a convenient method for adding new properties toapolysaccharide with minimum loss of its initial properties2