Grafting polydimethyl aminoethyl methaacrylate on hydroxyapatite nanoparticles via surface-initiated atom transfer radical polymerization

Hydroxyapatite nanoparticles are used widely in bone replacement and tissue engineering. Surface-initiated ATRP on HA particles using DMAEMA monomers is carried out in this work in order to obtain optimum mechanical properties in the resultant polymer-matrix composite. First, NH2-HA particles are synthesized using APTES, and then initiator-functionalized HA particles, Br-HA, are synthesized using 2-bromoisobutyryl bromide. Surface initiated ATRP is then carried out with DMAEMA monomers resulting in grafted-HA particles. FTIR and TGA tests are done to investigate the grafting of polymeric chains on the HA surface and to determine the grafting density of the chains. Results show a successful synthesis of grafted-HA particles that can be used in biomedical applications due to their enhanced mechanical properties

کلیدواژه ها:

Hydroxyapatite ، surface modification ، polydimethyl aminoethyl methaacrylate ، atom transfer radical polymerization