Preparation and evaluations of electrospun poly (lactic-co-glycolic acid)/Chitosan composite nanofibrous for wound dressing applications.

The basic function of the wound dressing is physical protection. Nowadays with new biopolymers and fabrication method, a wound dressing has excellent properties which improve the healing process. In this study, we fabricated chitosan/PLGA nanofibrous by a dual-electrospinning process for wound dressing applications. The morphology, structure, water uptake, porosity of the nanofibrous composite were investigated by scanning electron microscopy (SEM), Fourier transform infrared (FTIR-ATR), incubation in phosphate buffer solution. Comparison SEM images of PLGA, Chitosan, PLGA/Chitosan showed dual spinning does not effect on the morphology and structure of the membrane. Porosity was considered by surface-to-volume ratio. The FTIR-ATR spectrum indicated chitosan and PLGA absorption bands. This study indicated that the nanofibrous composite of nonwoven electrospun PLGA/Chitosan could be a good candidate for wound dressing

کلیدواژه ها:

electrospinning ، PLGA ، Chitosan ، wound dressing