Effects of solvent type on in vitro lidocaineHCl release from PLGA-based in situ forming systems

In this study, effects of solvent type on in vitro lidocaine HCl release from injectable in situ forming implants were investigated. For the preparation of the formulations, NMP and PEG400 were used as solvents while low molecular weight poly(DL-lactide-co-glycolide) (Resomer RG 502H) was used as polymer. The formulations showed low initial burst and acceptable regular release of drug for 21 days. Morphological analysis used as descriptive for in vitro release behavior of drug in in situ implant systems. As a conclusion encouraging results were obtained for the investigation of in situ implant systems.

کلیدواژه ها:

In situ implant ، lidocaine HCl ، Poly(DL-lactide-co-glycolide)