Effect of Drug on the Dynamic Mechanical Thermal Properties of Poly(L-lactide)

This paper investigates the influence of lidocaine hydrocholorid and progesterone on the dynamic mechanical thermal properties of PLLA matrix. Neat PLLA and PLLA containing drugs were prepared by solvent casting method after dissolving in dichloromethane. Dynamic mechanical thermal analysis (DMTA) was performed at a constant frequency of 1 Hz and a heating rate of 3 °C/min. The results show that the values tan δ peak slightly were shifted to lower values by incorporation of drug. At temperature below Tg, PLLA containing progesterone has a higher modulus than neat sample due to drug crystal form. Hydrophilic lidocaine hydrocholorid with polar characteristic can act as plasticizer leading to lower module value