Preparation of Poly L-Lactide/Triclosan Nanoparticles For Specific Medical Applications

This work aims on preparation of Poly-L-lactide (PLLA) / triclosan nanoparticles as antibacterial products used in specific medical applications. PLLA was synthesized by the reaction extrusion via ring opening polymerization of L-lactide. The PLLA/triclosan nanoparticles were prepared by the emulsification–diffusion process with fewmodifications. Chloroform was used for the surface reaction of triclosan without any chemical shifts. The resulted nanoparticles were characterized by the general experimental techniques. The synthesized nanoparticles with the controlled antibacterial activity could be considered as an appropriate alternative as antibacterial agent in the implantable surgical products as well as the drug delivery and wound-dressing applications

کلیدواژه ها:

Triclosan ، Poly L-Lactide ، PLLA grafted nano-triclosan ، Release Studies ، Antibacterial