Fabrication and Characterization of Gelatin Nanoparticles by Nanoprecipitation as a Delivery System for Erythromycin

The present study focuses on fabrication and characterization of erythromycin loaded gelatin nanoparticles by nanoprecipitation method. The process consists of adding the aqueous gelatin solution to the non-solvent phase containing lutrol F127. Three different crosslinker concentrations were also examined, the optimum of which was chosen as the fixed formula for the rest of investigations. The morphology of gelatin nanoparticles was characterized by FE-SEM. Nanoparticle size determination was carried out using a DLS system. The FTIR spectra of nanoparticles showed no harmful or unexpected bounds. Furthermore, release studies proved the suitability of these particles as a drug delivery system.