The combination of ROP and click chemistry for Preparation of core-shell MNP/PCL-PEG copolymer nanoparticles with AB and ABA morphologies

This study attempts to synthesize of block copolymers with capable of being targeted in drug delivery. A series of ABA- and AB-type nanoparticles based on poly(caprolactone) (PCL) and poly(ethylene glycol) (PEG) as a shell and magnetic nanoparticle (MNP) as a core were synthesized by click chemistry and thoroughly investigated. The properties of obtained polymers and nanoparticles were characterized by means of FT-IR and GPC. In vitro release profiles of all drug-loaded nanoparticles were studied. Generally, the prepared nanoparticles are suitable systems for drug delivery and their architecture makes them good candidates for programmable release systems Cytotoxicity of core-shell nanoparticles was investigated

کلیدواژه ها:

Block copolymers ، Drug delivery ، Magnetic nanoparticle ، Click chemistry ، Release