Synthesis of Amphiphilic Hydrogels based on Hyperbranched Polycaprolacton and PEG via Click Chemistry as a Drug Delivery System

Hyperbranched star-shaped amphiphilic hydrogels based on poly(e-caprolactone) (PCL) and poly(ethylene glycol) (PEG) have been synthesized via the combination of ring opening polymerization (ROP) and click chemistry. The swelling degree is determined in water. The results show that swelling behavior is noticeable because of more contribution of PEG in hyperbranched structures. Captopril as a model drug was loaded into hydrogels and investigation of drug release was carried out in PBS (pH=7.4) at 37°C.

کلیدواژه ها:

Hyperbranched polymers ، Amphiphilic hydrogel ، click chemistry ، drug delivery