Preparation And Release Evaluation Of Sumatriptan Succinate Oral Thin Films

Sumatriptan succinate is an antimigraine drug. The present investigation was undertaken with the objective of formulating Sumatriptan succinate fast dissolving oral thin films allowing drug dissolution in oral cavity thus bypassing first pass metabolism, to enhance the convenience and compliance by the elderly and pediatric patients. In the present study, Sumatriptan succinate fast dissolving films were formulated by solvent-casting method containing HPMC E6 as polymer, Glycerin, PEG 400, Sorbitol as plasticizer and Aspartame as sweetener. Three formulations were showing approximately 50-75% drug release after 2 min that the formulation containing sorbitol was showed faster release rate.