Synthesis and characterization of photo crosslinked maleic anhydride and poly (ethylene glycol)hydrogels

Poly (ethylene glycol) based hydrogels have attracted considerable interest in biomedical applications such as drug delivery, tissue engineering and etc. because of biocompatibility of this material. In this research using maleic anhydride (MA) and poly (ethylene glycol) (PEG) through half ester reaction, poly (ethylene glycol) di maleate crosslinker with 96% yield was synthesized and after characterization was used in hydrogel structure. Hydrogels solutions including same ratios of cross linker and acrylic monomer, special amounts of water and different concentrations of photo initiators were subjected to UV lamp to be cured. The effect of type and concentration of initiators on swelling behavior was investigated.Hydrophilic monomers, carboxylic acid end groups of the crosslinker enhanced their swelling behavior and have the potential tomake them PH sensitive. High amount of polymer fraction caused homogenous structure and considerable strength

کلیدواژه ها:

poly (ethylene glycol) ، maleic anhydride ، photo crosslinking ، hydrogel ، acrylic monomer