Thermoresponsivepolymeric hydrogels for cartilage tissue engineering

Injectable polymeric hydrogels have received consideration attention for biomedical applications. In this study, a novelthermosensitivehydrogel based on Pluronic, chitosan and keratin was designed for cartilage regeneration.The formation of polymer conjugates was confirmed by FTIR.The fabricatedcompositeunderwent a sol–gel transition under physiological conditions, highlighting its potential as an injectable hydrogel for cartilage regeneration. SEM images showed porous structure of hydrogel network. A decrease in the swelling ratio and biodegradation after chemical crosslinking with genipinwas also observed.These results suggested that the introduced hydrogel could serve as a new injectable biomaterial for cartilage tissue engineering.

کلیدواژه ها:

Injectable hydrogel-Thermosensitive-Pluronic-Chitosan-Keratin