Preparation and characterization of doxorubicin loaded folate modified carboxymethyl chitosan nanoparticles

The purpose of this article is developing doxorubicin loaded chitosan nanoparticles with the ability to target to the breast cancer tissues. In this study folate modified chitosan nanoparticles with the ability of selfassembling have been synthesized throughout the interaction of chitosan with folic acid in presence of Nhydroxysuccinimide (NHS), N,N-dicyclohexylcarbodiimide (DCC) and 1-ethyl-3-(3- dimethylaminopropyl)carbodiimide (EDC). Nanoparticle size and morphology of NPs were investigated by FE-SEM and drug loading efficiency (LE) and loading capacity (LC) of NPs were studied by UV-visible. Results show that molecular weight and degree of substitution of FA have direct effect on properties of nanoparticles. The results showed that folate modified carboxymethyl chitosan is able to form nanoparticles via undergoing intra- and/or intermolecular association between folic acid moieties in aqueous environment and these nanoparticles are able to encapsulate hydrophobic drugs, such as DOX with high LE. As molecular weight of chitosan decreased, size decreased and LE increased

کلیدواژه ها:

folate modified ، chitosan ، Carboxymethylation ، doxorubicin ، breast cancer