Magnetic nanocarrier coated by long polymeric spacer, highlystable for controlled delivery of doxorubicin

A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grownup onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylesterto increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release.

کلیدواژه ها:

Drug delivery ، Magnetic nanoparticle ، Dendrimer ، pH-responsive nanocarrier