Long-term effect of consumption Cistanche tubulosa for treating Alzheimer’sdisease

Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. This study was conducted to survey the effect of Cistanche tubulosa extract (CTE) on long-term treatment of AD. Materials and methods: 60 adult-male-Wister rats divided into 6 groups. In the first group 10 healthy rats were served as negative control (T1). Treatments 2 to 6 received 17 mg/kg Aluminum chloride (intragastric) for 30 successive days in order to induction of Alzheimer. T2 was positive control, T3 received 0.3 mg/kg ofRivastigmine tartrate (Exelon®) daily, and T4, T5 and T6 received 100, 200 and 400 mg/kg of ethanolic CTE for 90 days, respectively. In order to evaluation of Spatial acquisition Morris Water Maze (MWM) test was done at the end of the experiment and data were captured by video tracking camera (EthoVision XT). Results: Results indicated that T2 (48.53±5.41) had statistically significant difference with all treatments (P<0.05). Also, all treatments which received CTE required shorter time to find platform location compared to T3, but only T4 (5.08±1.08) and negative control (9.37±3.40) (P<0.05) indicated statistically significant difference. No significant difference was observedamong CTE groups (T4, T5 and T6) and negative control. Conclusion: The antioxidant and anti-inflammatory capacity of CTE is well-known in literature studies, on the other hand, some studies indicate neuro-regeneration effects of CT. Totally these effects makes CT a suitable candidate for treating AD. Thus, it is assumed that CTE could improve AD induced by Aluminum chloride by increasing antioxidant capacity (neuro-protecting) and neuroregeneration.

کلیدواژه ها:

Alzheimer’s disease ، Cistanche tubulosa ، Rivastigmine tartrate ، Morris Water Maze ، Long-termtreatment