Inhibitory effect and anticancer activities of maple syrup on the cell growth

cancerous tumors on all continents in prehistoric times. Maple syrup is a natural sweetener consumed by individuals of all ages throughout the world. Maple syrup contains not only carbohydrates such as sucrose but also various components such as organic acids, amino acids, vitamins and phenolic compounds. The purpose of study is to investigate the anticancer effect of maple syrup. A review of recent literature regarding maple syrup and cancer treatment. Literature searches in PubMed, Proquest, Informit, PsychInfo, and Geobase were conducted. Fifteen quantitative studies met the inclusion criteria for this Literature review. The majority of studies were cross-sectional and published after 1980. Recent studies have shown that these phenolic compounds in maple syrup may possess various activities such as decreasing the blood glucose level and an anticancer effect. In this study, we examined the effect of three types of maple syrup, classified by color, on the cell proliferation, migration and invasion of colorectal cancer (CRC) cells in order to investigate whether the maple syrup is suitable as a phytomedicine for cancer treatment. CRC cells that were administered maple syrup showed significantly lower growth rates than cells that were administered sucrose. In addition, administration of maple syrup to CRC cells caused inhibition of cell invasion, while there was no effect on cell migration. Administration of maple syrup clearly inhibited AKT phosphorylation, while there was no effect on ERK phosphorylation. These data suggest that maple syrup might inhibit cell proliferation and invasion through suppression of AKT activation and be suitable as a phytomedicine for CRC treatment, with fewer adverse effects than traditional chemotherapy. Studies have shown that these phenolic compounds in maple syrup are suitable for cancer treatment especially colorectal cancer (CRC).

کلیدواژه ها:

Colon cancer ، Cell proliferation ، Cell invasion ، AKT ، Phytomedicine