Antihyperglycemic and antihyperlipidemic activeities of Nannochloropsis oculata microalgae in streptozotocin-induced diabetic rats

Introduction: It is well documented that biological active components of microalgae have therapeutically potential for treatment of different diseases. In current investigation, we assessed antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae (NOM) in Streptozotocin (STZ)-induced diabetic male rats. Materials and methods: The rats were placed in two sections (healthy and diabetic). In our investigation, 2.5-month-old male rats (n=10/diet treatment) were orally treated with NOM at rates of 10 and 20 mg/kg of body weight for 3 weeks. Thus treatments included: 1. NOM10 in healthy rats, 2. NOM 20 in healthy rats, 3. NOM 10 in diabetic rats, 4. NOM 20 in diabetic rats, 5. healthy control rats were treated with 0.3 ml of distilled water, and 6. diabetic control treated with STZ (mg/ml). Body weight (BW) was measured each week during the experiment. At the end of the trial, blood samples were taken for measurement of glucose, insulin, cholesterol, total bilirubin, triglycerides, HDL-C, LDL-C, albumin, total protein, creatinine, uric acid, aspartate amino transferase, alanine amino transferase, and alkaline phosphatase. Results: Our findings showed that diabetic rats treated with NOM have a significant lower glucose, cholesterol, triglycerides, or LDL levels and higher insulin and HDL-C (P<0.05) levels in the serum concentrations of, and higher the serum concentration of. Treatment with NOM had no significant effect on blood parameters in healthy rats (P>0.05). Also, NOM could maintain body weight in diabetic rats (P<0.05). Conclusion: It is concluded that NOM has antihyperglycemic and antihyperlipidemic activities in diabetic rats

کلیدواژه ها:

Diabetic rat ، Glucose ، Insulin ، Microalgae