KH2Po4: An efficient catalyst for the one-pot synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones derivatives under thermal and solvent-free conditions

KH2Po4 as an efficient and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with short reaction times and excellent yields is reported. The most benefits this procedure is such as inexpensive and non-toxic catalyst, eco-friendly, solvent-free conditions, simple operational procedures, environmentally benign nature, one-pot, excellent yields.

کلیدواژه ها:

KH2Po4 ، 3 ، 4-Dihydropyrimidinone ، Biginelli reaction ، Multi-component synthesis