Synthesize and characterization of theranostic radio-MOF nanoparticles containing Cu-64 and Y-90 for treatment of metastatic bone cancer

Here MOF concept is contributed to the preparation of a novel theranostic bone-seeking agent with different sizes, composed of Cu-64, Y-90, and DOTMP for treatment of bone metastases. The products were characterized (IR, elemental analysis: CHN, ICM-MS, PIX, DLS) quality-controlled (RTLC). The stability was checked up to one week at 37ᵒC in human serum. Biodistribution studies up to 72 h were performed. Radio-MOF crystals and colloidal radio-MOF nano particles (80±20 nm) obtained by varying the synthesizing conditions (including pH and temperature), showed similar IR patterns and similar elemental analysis results. The chemical formula was [1Y-1Cu-1DOTMP] for both. The final product was synthesized at pH=8, stirring at room temperature using carrier free Y-90 and Cu-64 and DOTMP (yield > 99%, RTLC) with an average size of 80nm. The stability and in vitro hydroxyapatite binding were checked up to one week at 37ᵒC in human serum.

کلیدواژه های Synthesize and characterization of theranostic radio-MOF nanoparticles containing Cu-64 and Y-90 for treatment of metastatic bone cancer:

MOF ، Cu-64 ، Y-90 ، DOTMP ، bone metastases