Synthesis of biologically active compounds: N-cyclohexyl-3-oxo-2-(3-oxo-2-azaspiro[4.5] decan-2-yl)-3- arylpropanamide

An intermolecular Ugi reaction of 2-(1-(aminomethyl)cyclohexyl)acetic acid (gabapentin) with glyoxal and cyclohexyl isocyanide and tertbutyl isocyanide under mild conditions in ethanol has been developed to produce a novel class of N-cyclohexyl-3-(aryl)-3-oxo-2-(3-oxo-2-azaspiro[4.5]decan-2- yl)propanamidein good to excellent yields. This represents the first report for the intermolecular Ugi three component reactions of gabapentin, glyoxal, and an isocyanide

کلیدواژه ها:

Gabapentin ، N-Cyclohexyl-3-(aryl)-3-oxo-2-(3-oxo-2-azaspiro[4.5]decan-2- yl)propanamide ، Intermolecular Ugi ، four-center