Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS

Background: Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulinmetabolism have been hypothesized to be involved in its etiology. Objective: We examined the possible association of adiponectin and insulinreceptor gene polymorphisms with PCOS. Materials and Methods: A total of 186 women with PCOS using NIH criteria and156 healthy women were recruited. Their samples were genotyped for thepolymorphism in exon 17 and 8 of the insulin receptor gene or exon and intron 2 ofthe adiponectin gene. Results: The distributions of genotypes and alleles of both polymorphisms were not different in women with PCOS and controls. There was no significant differences onthe anthropometric and hormonal profiles of various adiponectin and insulin receptor genes polymorphisms among both groups. Conclusion: Adiponectin and insulin receptor gene polymorphisms are not associated with PCOS in a sample of Iranian population

کلیدواژه ها:

Receptor ، Insulin/ genetics ، Adiponectin/ genetics ، Polycystic ovary syndrome ، Polymorphism ، Genetic/ genetics