Heterogeneity of pathogenesis in Multiple Sclerosis and complications of the diagnosis and therapy

Multiple sclerosis is a chronic demyelinating disease of the central nervous system (CNS) with either a relapsing–remitting (RR) or a chronic course andis a common cause of disability in young adults. Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, neuroradiological appearance of the lesions, involvement of susceptibility gene loci, and response to therapy. These features are supported by experimental evidence, which demonstrates that fundamentally different processes, such as autoimmunity or virus infection, may induce MS-like inflammatory demyelinating plaques and suggest that MS may be a disease with heterogeneous pathogenetic mechanisms.

کلیدواژه ها:

multiple sclerosis ، neurodegeneration ، inflammation pathophysiology ، histopathology