Designing the analog of cyclic peptide cyclosaplin, cyclosaplin-7R, and determining anti tumor activity with bioinformatical perspectives
محل انتشار: دومین همایش ملی تازه های سلولی و مولکولی
سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 495
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شناسه ملی سند علمی:
NCNCMB02_136
تاریخ نمایه سازی: 12 تیر 1395
چکیده مقاله:
Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer treatment. Recently, a Small cyclic peptides cyclosaplin exhibited potent biological activity have great potential for anticancer therapy. In this study, a novel peptide, cyclosaplin-7R designed according to the structure, charge, hydrophobicity,helixicity and SVM parameters. Also we investigated the antitumor activity of cyclosaplin-7R by Anticp software . Moreover, our bioinformatical studies showed that cyclosaplin-7R had great anticancer activity while some in-vitro experiments against some immortalized cell line (MDA-MB-231) must be performed in next of this study. In conclusion, cyclosaplin-7R could be a new effective drug for cancer research as much as cyclosaplin.
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