Assessment of the chitosan coated Fe3O4 nanoparticles effects blood and renal factors on the wistar rat

Background: Iron oxide nanoparticles have wide applications such as MRI contrast agent and drug delivery. Nevertheless, their effects on human health have not been fully investigated yet. After cellulose, chitin is one of the most abundant organic materials in nature which is widely used in food industry, cosmetics, agriculture, medicine and the environment. In this study, the effect of chitosan coated iron oxide nanoparticles on the hematological and renal factors is investigated.Materials and Methods: 60 adult female Wistar rats were divided into 10 equal groups. Concentrations of 50, 100 and 150 mg per kg of rat body weight from chitosan, iron oxide nanoparticles and chitosan coated nanoparticles were intraperitoneally injected into 9 groups and the last group was selected as the control group who received just normal saline. Then, blood samples were collected directly from the rat heart in the days 15 and 30 post injection and blood parameters (WBC, RBC) and renal parameters (urea, creatinine, uric acid) were measured.Results: The results was analyzed by the SPSS 20 software(One way ANOVA) and there is not a significant differences in the levels of urea, creatinine and uric acid compared to control group. But the average number of blood cells (WBC and RBC) in the groups treated with higher concentrations of ٥٠

کلیدواژه ها:

toxicity ، chitosan ، nanoparticles ، iron oxide ، rat