A three component one-pot procedure for the synthesis of benzimidazoloquinazolinone derivatives in the presence of Carboxymethyl Cellulose as a green and reusable catalyst

The growth of organic synthesis has been facilitated by the development of one-pot methods, since they are atom economic, environmental friendly, generate less waste, minimize the need of isolation of intermediates in multistep synthesis of complex molecular targets, save time and minimize cost. [1]In the present study, the authors examine the catalytic behavior of Carboxymethyl Cellulose as a catalyst for the coupling reaction. In this procedure, the products were easily isolated by simple filtration; no need for column chromatography and further recrystallization. We report here a high-yielding, one-pot synthesis of quinazolinone derivatives under convenient conditions. The conditions are mild, and a wide range of functional groups can be tolerated. Using Carboxymethyl Cellulose as catalyst offers advantages, including simplicity of operation, easy workup, the recyclability of the catalyst, and good yields of products.

کلیدواژه ها:

Multi-component reaction ، one-pot procedure ، Benzimidazolo-quinazolinone ، Carboxymethyl Cellulose ، Heterogeneous and Reusable catalysts