Effect of different factors on rivastigmine loading in chitosan nanoparticles

Chitosan as a natural polymer, with good biocompatibility, biodegradability and non-toxicity have beenwidely used in biomedical applications. Chitosan nanoparticles with appropriate particle size and also ability totransverse the blood brain barrier, have wide applications in targeted drug delivery to the brain. In this study, weattempt to optimize nanoparticles size and process yield of chitosan nanoparticle preparation through ionic gelationusing Design Expert 7.0.0. Finally, the influence of parameters such as temperature, chitosan molecular weight and theratio of drug to polymer were investigated. It was found that, the ratio of drug to polymer and chitosan molecularweight are the most efficient parameters.

کلیدواژه ها:

Chitosan ، Nanoparticles ، Rivastigmine ، Drug Loading