Development of chitosan nanoparticles: a slow release drug delivery system

Chitosan nanoparticles have been widely used as carriers for therapeutic proteins and drugs. This study attempts to usethe ionic gelation fabrication method, and associated processing conditions under which drug encapsulation and release can beadjusted so as to reach desired effectiveness. Dexamethasone (DEX) was used as a model drug which was encapsulated using thepolyanion tripolyphosphate (TPP) as the crosslink agent to form chitosan–DEX–TPP nanoparticles. The drug-loaded chitosannanoparticles were characterized for encapsulation efficiency, and subsequent release studies, which were dependent on thetemperature of crosslinking process, chitosan concentration, and initial drug amount.

کلیدواژه ها:

Chitosan ، Nanoparticles ، Dexamethasone ، Drug Release