Simvastatin Nanoparticles Formation by Rapid Expansion of Supercritical Solution (RESS) Process and Study the Effect of Extraction Temperature on Particle Size

One of the main factors in efficacy of pharmaceutical molecules is the value of their bioavailability thatincreases by the reduction of particle size since the dissolution rate is enhanced. In this study, simvastatin (a poorwater soluble drug) nanoparticles were formed by Rapid Expansion of Supercritical Solution (RESS). The effect ofextraction temperature (30-50 °C), was investigated on size and particle size distribution of the nanoparticles and itwas found that by increasing extraction temperature, particle size is decreased. Particles were characterized usingScanning Electron Microscopy (SEM). Dissolution rate study shows a 4-fold increase in dissolution rate ofnanoparticles compared to the original particles.

کلیدواژه ها:

Simvastatin ، Nanoparticle ، Supercritical Fluid Technology ، Extraction Temperature ، Dissolution Rate