Preparation and in vitro aerosol performance of spray-dried alendronate loaded solid lipid nanoparticles in carrier- based dry powder inhalers

This study aimed to develop inhalable solid lipid nanoparticles (SLNs) of the alendronate containingmannitol as carrier by spray-drying method. Simple homogenization method was applied for preparation ofSLNs.Scanning electron microscopy showed spherical particle morphology with smooth surfaces for the spray-driedparticles. In vitro deposition of the aerosolized drug was performed using a Next Generation Impactor (NGI) at 60L/min following the methodology illustrated in the European and United States Pharmacopeias. The prepared spraydriednanoparticulate-on-microparticles dry powder displayed excellent aerosol dispersion performance as drypowder inhalers (DPIs) with high values in emitted dose (ED), fine particle fraction (FPF), and mass medianaerodynamic diameter (MMAD). The aerosol dispersion performance of the particles in the presence of mannitolshowed that the prepared powder could be good candidates for DPI application.

کلیدواژه ها:

Solid Lipid Nanoparticle ، alendronate ، dry powder inhaler ، mannitol