Niosomal formulation prepared by the novel method of phosphate gradient

This study examines a new method for the remote loading of niosomal formulation, by using phosphate gradient. Dorzolamidehydrochloride (Dorzo); one of the antiglaucoma drugs; was to formulate and characterize in non-ionic surfactant vesicles (niosomes) as anocular carrier. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoesters (Span 60) in various molar ratio of lipid to drug andvarious cholesterol amount. During preparation, the influence of the intravesicular and extravascular pH and molarity in theencapsulation efficiency of Dorzo was investigated.The formulation were characterized using Zetasizer, scaning electronmicroscopy (SEM), calculating percent drug entrapmentefficiency and cumulative percent released. Z-average sizes of the niosomes were between 100 and 185.5 nm. Dorzo was successfullyentrapped in all of the formulations with entrapment efficiencies rangingbetween 1.7% and 46.7%.

کلیدواژه ها:

Niosome ، dorzolamide Hcl ، none-ionic surfactant ، phosphate gradient