Application of a nanoporous metal organic framework based on iron metal as potential drug loading and delivery system

In the present study, nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligandMIL-101-NH2-Fe has been used as a carrier for loading and in vitro release 5-flurouracil (5-FU) anticancer drug. The drug loading ofthe dehydrated MOF was measured 13 wt % by decreasing weight analysis. The 5-flurouracil delivery was monitored underphysiological conditions at 37°C, pH 7.4 in simulated body fluid (SBF) for 6 days by spectrophotometry. The MOF was characterizedby X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), UV– vis spectroscopy, and scanning electron microscopy(SEM).

کلیدواژه ها:

MOF ، MIL-101 ، 5-flurouracil