Investigation of the bottom-up approach to production of Indomethacin nanoparticles

In this study production of the nanoparticles of Indomethacin as a poorly water-soluble drug based on liquidantisolvent precipitation process was investigated. In this way the Continuous antisolvent production of drugnanoparticles was carried out with a confined liquid impinging jets. The SEM photomicrographs shown that theIndimethacin nanoparticles exhibited needle-like morphology and uniform PSD when compared to irregular shapecommercial Indomethacin. The result also indicated that the nanoparticles of Indomethacin can be prepared under theincreasing the drug concentration from 10mg/ml to 30mg/ml.

کلیدواژه ها:

precipitation ، impinging jets ، Indomethacin ، solvent mixture ،