Synthesis and characterization of cyclodextrin nanogel for drug delivery

Nanosized hydrogels (nanogels) have attracted enormous attention as multifunctional polymerbaseddrug delivery systems. Their efficiency is demonstrated both in drug encapsulation and drug release. In this work,we designed a novel nanogel polymer synthesized from chemically crosslinked alginate, using β-cyclodextrin (β -CD)that plays a dual role as a crosslinker and as a host molecule for enhanced binding of anticancer drug capecitabine (CAP),to achieve high drug loading level as well as controlled and sustained release of the anticancer drug. For this purpose, aseries of novel β –CD crosslinked alginate were synthesized. The loading, complexation, and release of CAP in or fromthe nanogel were investigated.

کلیدواژه ها:

Nanogel polymer ، cyclodextrin ، alginate ، drug delivery