Role of surface modification on sustain release of diphenhydramine hydrochloride from halloysite nanotubes

سال انتشار: 1393
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 548

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شناسه ملی سند علمی:

ICNN05_177

تاریخ نمایه سازی: 30 آبان 1394

چکیده مقاله:

Halloysite nanotubes (HNTs) are promising carrier for the controlled release of drugs. In this paper, surface hydroxyl groupsof halloysite experienced an alteration following two steps modification. Firstly 3-aminopropyltriethoxy silane (APTES) wasintroduced to surface OH groups of HNT in order to obtain amine functional groups. Subsequently, maleic anhydride partiallytransformed NH2 groups to form carboxylic acid functionalized halloysite nanotubes, considering a medium yield of thereaction. Diphenhydramine hydrochloride (DPH) has been selected as a model cationic drug. Surface modification and thermaldecomposition behavior of samples were investigated by Fourier transform infrared spectroscopy (FTIR) and derivativethermogravimetric analysis (DTGA). Loading and subsequent release of DPH on modified and unmodified nanotubes wereevaluated by Uv-visible spectroscopy. Results suggest that the engineered surface modified nano carrier has the capability toimprove both drug uptake and sustain release due to the strong electrostatic interactions between DPH molecules and anioniccarboxylate groups with located on HNT surfaces.

نویسندگان

H Hematpour

Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

V Haddadi-Asl

Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

S.S Zargarian

Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran