Synthesis and Evaluation of new Chitosan Nanoparticles as New Carrier for Intravenous Delivery

Commercial lipid emulsion of propofol (CLE) has several drawbacks including pain on injection andemulsion instability. A novel nanocarrier system is introduced to improve stability and solubility of poorly soluble drug,propofol, for intravenous administration. Chitosan is modified using a facile novel method in which chitosan grafted tomethoxy polyethylene glycol (mPEG) then employed to prepare nanoparticles for encapsulation of propofol. Analysisrevealed that nanoparticles have the average particle size of 80 nm±1.2 and spherical morphology which is less than CLEwhile their pH, osmolarity and profile of release of formulated nanoparticles are similar to those of CLE. In addition, theresults show good chemical and physical storage stability for the nanaparticles at room temperature for at least 6 monthcompared to CLE as control. Animal sleep recovery test on rates shows no significant difference in time ofunconsciousness and recovery of righting reflex between nanoparticles and CLE.

کلیدواژه ها:

Propofol ، PEG-grafted chitosan ، Nanoparticles ، Anesthetic ، Poorly soluble drugs