Targeted delivery of doxorubicin loaded magnetic nano carriers of dextran-spermine surface functionalized with Anti-HER2 for chemotherapy in breast cancer

Reducing systemic side effects of anticancer drugs is one of the major challenges of pharmaceuticalresearchers. One of the simple solutions is preparation a theranostic nanoparticle (NPs) system by using monoclonalantibody beside anticancer drugs. In this study we prepared doxorubicin loaded magnetic polymeric NPs by usingdextran-spermine as a cationic polymer based on the ionic gelation method. Sodium tripolyphosphate (TPP) were usedas a crosslinker and nanoparticle’s surface functionalized with anti-HER2. Process parameters such as concentration ratioof TPP to dextran-spermine, doxorubicin to dextran-spermine and pH were fully investigated. The mean particle size ofthe NPs determined by dynamic light scattering was in the range of 62-134nm and the doxorubicin entrapment efficiencywas obtained 58% at the optimum condition. These result represent that these doxorubicin loaded nanoparticles have ahigh drug loading capacity and appropriate release profile for anticancer drug targeting delivery.

کلیدواژه ها:

dextran-spermine ، doxorubicin ، magnetic nanoparticle ، breast cancer HER2 positive ، active targeting