A novel design of plexcitonic-based Aptamer Nanobiosensor for detection of cTnI

Acute myocardial infarction (AMI) is one of leading cause of death throughout the world. A novelultrasensitive, fluorescent, plexcitonic based aptananobiosensor is developed for detecting cardiac troponin I (cTnI), thegolden biomarker of AMI. Plexcitonic hybrid system is made by hybridization of bioconjugated quantum dots andbioconjugated Au nanoparticles by a cTnI-aptamer. Binding of cTnI protein to aptamer, probably causes scatting ofquantum dots from Au nanoparticles; leading to fluorescence quenching of plexcitonic hybrid system. It seems that thisnovel design of plexcitonic hybrid system can open up new opportunities in perspective of nanobiosensor progress

کلیدواژه ها:

Acute Myocardial Infarction ، Plexcitonic ، Cardiac Troponin I ، Aptamer ، Nanobiosensor