The effects of topical chloramphenicol and ciprofloxacin on conjunctival bacterial flora of healthy dogs

  • سال انتشار: 1394
  • محل انتشار: فصلنامه طب دامی ایران، دوره: 9، شماره: 1
  • کد COI اختصاصی: JR_IJVM-9-1_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 611
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نویسندگان

A Mahmasi

Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

M Selk Ghaffari

Department of Clinical Sciences, School of Veterinary Medicine, Islamic Azad University-Karaj Branch,Karaj, Iran

G Sadeghi-Hashjin

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

M.R Davoodi

Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

چکیده

BACKGROUND: Normal bacterial flora of the conjunctiva,which inhibits growth of opportunistic organisms, has animportant role in the prevention of ocular infections. If residentflora is inhibited by disease or long-term application ofantibiotics, opportunistic pathogens overgrow, leading to disease.OBJECTIVES: The aim of this study was to investigatethe effects of ophthalmic chloramphenicol and ciprofloxacinon bacterial conjunctival flora in healthy dogs. METHODS: Atotal of 16 animals were divided into 2 equal groups whichreceived either chloramphenicol (CHL) (0.5%) or ciprofloxacin(CIP) (0.3%). In both groups, the right eye of each animalwas treated with 2 drops of antibiotics every 8 and 6 hours,respectively, for 1 week and the left eye received artificial tearsolution and served as control. Bacterial and fungal cultureswere performed 8 hours before and after the treatment. Fisher’sExact test and SPSS software were used for statistical analyses(p< 0.05). RESULTS: There were no statistically significant differencesbetween control and test eyes and bacterial isolates inboth groups. In CHL group, after treatment Staphylococcus spp(62.5%), Bacillus spp (12.5%) from the right eyes and Staphylococcusspp (75%) and Bacillus spp (12.5%) from left eyeswere isolated. In CIP group, after treatment the bacterial isolatesof right eyes were Staphylococcus spp (87.5%), Aerococcusspp (37.5%), Viridans streptococcus (25%), Micrococcusspp (12.5%), Bacillus spp (12.5%); Staphylococcus spp (75%),Micrococcus spp (25%), Bacillus spp (12.5 %) were isolatedfrom left eyes of dogs after 1 week administration of artificialtear. CONCLUSIONS: Topically applied chloramphenicol and ciprofloxacinhad no significant changes in or detrimental effectson normal bacterial flora of treated dogs.

کلیدواژه ها

chloramphenicol, ciprofloxacin, conjunctival flora, dog

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