Evaluation of biopolymers blend hydrogel as a biopaper for cell and organ printing application: an in vitro study
محل انتشار: هفتمین کنگره ملی مهندسی شیمی
سال انتشار: 1390
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 868
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شناسه ملی سند علمی:
ICHEC07_442
تاریخ نمایه سازی: 25 فروردین 1394
چکیده مقاله:
Recent advances in tissue engineering strategies have led to the development of the concept of tissue or organ printing- a biomedical application of rapid prototyping technology that offers an interesting alternative to traditional solid scaffold-based tissue engineering. Biopaper is a bioprocessible biomimetic hydrogels that specially designed for the bioprinting process. In the present work, four different weight percentage ratios (100:0, 75:25, 50:50, 25:75) of agarosegelatinblend hydrogels have been studied for the construction of biopaper for bioprinting application. Prepared hydrogels were characterized in terms of gel point temperature, mechanical stability, morphological observation, glucose diffusion and in vitro degradation. Tissue fusionstudy was performed on Chinas Hamster Ovary cell aggregates embedded into the hydrogel. Based on obtained results, sol-gel transition point for samples with quite the same proportion of two components was in the physiological condition range (35-37°C). By adding gelatin content ofhydrogels young’s modulus decreased about 4.5 times; furthermore, less denser network with larger pores were resulted that provided glucose diffusion into hydrogels. Amount of degradation linearly decreased by enhancing agarose part of samples. Evaluation of tissue fusion process onsample of 50:50 demonstrated relative permissivity of blend hydrogel with time scale of τcc = 60 h. Considering the result of this study, agarose-gelatin blend hydrogel with the same proportion of two components is capable to utilizing as a biopaper for bioprinting technology.
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نویسندگان
r Imani
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Razi Institute for Drug Research and Department of Pharmacology, Tehran University of Medical sciences,Tehran, Iran
s Hojjati Emami
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
a.m Sharifi
Razi Institute for Drug Research and Department of Pharmacology, Tehran University of Medical sciences,Tehran, Iran
p Rahnama Moshtaq
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
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