The role of two common genetic variants of F13A1 and F V Leiden gene with Uterine myomas in women from south of Iran

A uterine myoma is a solid benign tumour that grows within the muscle tissue of the uterus and occurs in 20%-40% of women in their productive age.(1) Myoma is a multifactorial disorder and exact reason of its incidence is not clarified till now. Coincidence of solid tumors and thrombosis is proved in many studiestherefore genetics factors involved in thrombosis could play critical roles in occurrence of myoma. Factor XIII that is encoded by F13A1 gene, is one of the most important factors in coagulation cascade and a SNP in nucleotide at position 102 of F13A1 gene (rs5985) is associated with thrombosis disorders (2). Anotherpolymorphism that is well-known as a major risk factor for thrombosis is found in F5 gene (rs6025) this geneticvariant is also called FV Leiden. People with heterozygote and homozygote genotype for this mutation has shown 2.7 and 18 fold increase in risk of thrombosis respectively (3). In this study we surveyed association between two polymorphisms in F13A1 and F5 genes and risk of myoma inwomen in south of Iran. Methods: we evaluated rs5985 and rs6025 mutation in extracted DNA from 70 women suffering from myomaand 70 healthy as a control group by ARMS-PCR method. Results and Discussions: a significant relationship between rs5985 and myoma has been revealed in this study (P=0.00193) although we fund no association between rs6025 and incidence of myoma in participants in our study