Association between genetic polymorphism of catalase (CAT) C-262T, Cu/Zn superoxide dismutase (SOD1) A251G and risk of Age-related macular degeneration (AMD)
سال انتشار: 1393
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 892
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شناسه ملی سند علمی:
CIGS13_0051
تاریخ نمایه سازی: 7 بهمن 1393
چکیده مقاله:
Purpose: Cells have complex network of antioxidant enzymes that protect cells from induced damages by reactive oxygen species (ROS). In considering that catalase and superoxide dismutase are as a primary protection against oxidative stress, also oxidative stress is as an important risk factor in age-related macular degeneration disease (AMD), we investigated the possible association between genetic polymorphisms of catalase (CAT) C-262T, Cu/Zn superoxide dismutase (SOD1)A251G and risk of exudative AMD. Methods: The study included 112 exudative AMD patients and 112 healthy controls. Genotyping of CAT C-262T and SOD1A251G were done by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.Differences in the frequencies were estimated using the χ2 test and risk was estimated with a logistic regression afteradjusting for smoking, working place and age status. Results: There was significant difference between CAT CT+TT genotype and AMD disease (P=0.009, OR=0.38, 95%CI=0.18-0.78). Also T allele has a significant association with risk of AMD and decreases risk of disease (P=0.036, OR=0.59, 95%CI=0.36-0.96), but there was no significant differences between SOD1A251G and variant homozygous and heterozygous frequencies in patients compared to controls (P=0.589, OR=0.77, 95%CI=0.3-1.96). Conclusions: According to a recent study, T allele in CAT genotypes increases catalase enzyme expression and activity, this increased level of CAT reduces the rate of reactive oxygen species (ROS). As a result, current study suggests T allele in CAT genotypes decreases risk of AMD.
کلیدواژه ها:
Age-related macular degeneration (AMD) ، Catalase (CAT) ، Cu ، Zn Superoxide dismutase (SOD1) ، Polymorphism
نویسندگان
Saghar Yousefnia
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Mostafa Saadat
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Iraj Saadat
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
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