(NH4)2SO4: as efficient, clean and inexpensive catalysts for the three-componentsynthesis of α-amino nitriles

The Strecker reaction is one of the most important multicomponent reactions in organic chemistry for the one-pot synthesis of α-aminonitriles. They serve as efficient precursors for the synthesis of natural and unnatural α-amino acids and different nitrogen containing heterocycles .They are also very effective intermediates for the preparation of different diamines, amides and pharmaceuticals. The α-amino acids have gained immense importance due to their significant biological activities. α-Aminonitriles are important intermediates for the synthesis of α-amino acids and various nitrogen containing heterocycles such as imidazoles and thiadiazoles, etc.In continuation of our work to develop new catalysts for organic transformations, here we report mild, efficient and environmentally benign catalyst for the preparation of α- aminonitriles from aldehydes, amines and trimethylsilyl cyanide in the presence of (NH4)2SO4 in ethanol at room temperature.

کلیدواژه ها:

α-Aminonitriles ، aldehydes ، imidazoles ، trimethylsilyl cyanide