Investigation of Rotavirus Diarrhea by Antigen Detection and Its Association With Paraclinical Factors in Hospitalized Children With Gastroenteritis

Background and Aim: Rotavirus is one of the most important causes of acute gastroenteritis in children under five years of age. This study aimed to investigate the prevalence of rotavirus and its association with laboratory parameters in hospitalized children. Materials and Methods: This cross-sectional study was conducted on ۱۹۹ children with diarrhea at Hazrat Masoumeh Children’s Hospital in Qom City, Iran, during ۲۰۱۴–۲۰۱۵. Stool samples were examined for rotavirus antigen using the antigen detection method, and complete blood count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were analyzed. Data were analyzed using SPSS software, version ۲۲ and appropriate statistical tests. Results: The prevalence of rotavirus was ۲۰.۱%. No significant differences were observed between gender or season and rotavirus infection (P>۰.۰۵). In the comparison between groups, the mean white blood cell (WBC) count was lower in the rotavirus-positive group than in the negative group, while the mean erythrocyte sedimentation rate (ESR), CRP, and polymorphonuclear leukocyte levels were also lower in the infected group compared to the non-infected group (P<۰.۰۵). Furthermore, fecal white blood cell (WBC) and red blood cell counts were higher in the positive cases. Conclusion: Rotavirus remains a significant cause of diarrhea in children and may be associated with alterations in laboratory parameters.

کلیدواژه ها:

Rotavirus ، Acute gastroenteritis ، Diarrhea ، Children ، Paraclinical