Fluid-structure Interaction Analysis of Intracranial Atherosclerosis Disease (ICAD): Moderate and Severe Stenosis Cases

This study investigated the effects of Intracranial Atherosclerosis Disease (ICAD) severity on vessel hemodynamics and structural response using one-way Fluid–Structure Interaction (FSI) simulations performed in ANSYS ۲۵, comparing moderate (۵۰% stenosis) and severe (۷۰% stenosis) cases. A validation experiment was also conducted to support the simulation results. Key parameters including velocity profile, pressure drop, wall shear stress, flow vectors, total deformation, equivalent stress, and equivalent elastic strain were analyzed throughout the cardiac cycle. The results showed that increasing ICAD severity significantly altered both hemodynamic and structural behavior. Compared to ۵۰% stenosis, the ۷۰% stenosis model exhibited a ۷۰.۵% increase in maximum velocity, ۶.۷۴% higher pressure, and ۲۰.۹% higher wall shear stress. During peak systole, pressure drops were ۶.۶% for ۷۰% stenosis and ۱.۱% for ۵۰% stenosis. Structural responses also increased, with deformation, equivalent stress, and elastic strain rising by approximately ۱۸%, ۱۷%, and ۱۸.۱%, respectively, concentrated near the stenotic region.

کلیدواژه ها:

Intracranial atherosclerosis disease (ICAD) ، Fluid-structure interaction (FSI) ، Computational fluid dynamics (CFD) ، Stenosis severity ، Hemodynamics