Tamsulosin versus Kidstone for Renal Colic Treatment after Discharge from Emergency Room: A Randomized Clinical Trial

Introduction: Renal colic is a severe and sudden flank pain, mainly caused by obstruction of the urinary tract by ureteral stones. Therefore, pain relief is the first step in managing affected individuals. Accordingly, the present study compared the use of the herbal Kidney Stone capsule as a new therapeutic approach with the use of Tamsulosin as the standard and routine treatment for reducing renal colic.Methods: This double-blind, randomized controlled clinical trial was conducted in ۲۰۲۴ at Al-Zahra and Kashani Hospitals in Isfahan, Iran. Patients presenting to the emergency departments with renal colic were randomly allocated to two treatment groups. Group ۱ (G۱) received tamsulosin (۰.۴ mg), while Group ۲ (G۲) received Kidstone capsules. Both groups also received diclofenac suppositories. The study was designed as a double-blind trial. Data were collected using a standardized checklist, the Visual Analog Scale, and the Numerical Rating Scale.Results: A total of ۱۱۵ patients (۵۷ patients in group ۱ and ۵۸ patients in group ۲) were enrolled in the study. The mean age of the patients was ۴۶.۰۲±۹.۷۸ years (range: ۱۸ to ۶۵ years), the body mass index indicated overweight in the patients, and ۶۴ patients (۵۵.۷%) were male. Pain severity in the two groups differed significantly during the first ۷۲ hours after initiation of treatment (P-value<۰.۰۵), being significantly higher in group G۱ compared to group G۲. Pain at ۷۲ hours, one week, and two weeks after treatment initiation also showed significant differences between the two groups (P-value<۰.۰۵), with the number of patients experiencing pain being significantly higher in group G۱ at all three follow-up points. Conclusion: Based on the results, the use of Kidstone capsules can be recommended for reducing pain and its severity in patients with renal colic. Its effects were observed from ۷۲ hours after administration and it was free of short-term side effects. Considering that this capsule is domestically produced, more affordable, and plant-based, it may be more favorably received by patients for use.

کلیدواژه ها:

tamsulosin ، Kidstone Capsule ، Renal colic ، Pain