Oligodendrogliomas A report of ۳۵ cases

Introduction: Oligodendrogliomas are not common intracranial neoplasms. We retrospectively reviewed all of the gliomas operated in Ghaem Hospital between the years ۱۹۸۱ and ۲۰۰۰ and found only ۳۵ cases of oligodendrogliomas (۷.۶% of total gliomas). survival analyses were performed on possible prognostic factors including: patient age and sex, presence of seizure, site, size, side, and treatment(extent of surgical resection, radiation dose, chemotherapy).Materials and Methods: Thirty-five patients with supratentorial oligodendrogliomas consisting of ۲۷ males (۷۷.۱%) and ۸ femals (۲۲.۹%) ranging in age from ۴ to ۶۸ years (mean age ۳۶.۹ years). Seizures were present in ۲۰ patients (۵۷%), headache in ۲۰ patients (۵۷%), vomiting and papilledema in ۱۵ patients (۴۳%), hemiparesis in ۱۲ patients (۳۴.۳%). The surgical treatment of the ۳۵ patients included gross total removal in ten patients (۲۸.۸%)and subtotal removal (including one patient who had only a biopsy) in ۲۵ patients (۷۱.۲%). All patients had subtotal resection received postoperative radiation(median۵۰۰۰ rad), in patients whose tumors were progressed (ten patients) received further surgery and chemotherapy treatment were necessary.Result:Thirty-five patients with supratentorial oligodendrogliomas underwent surgery plus postoperative radiation and chemotherapy between the years ۱۹۸۱-۲۰۰۰. The median survival time and the ۵-۱۰ and ۱۵ year survival rates for these ۳۵ patients were ۵.۶years,۵۴%, ۳۴%, and ۲۴%.Conclusion: Patients with pure oligodendrogliomas had better median survival time, approximately ۵.۶ years, respectively, compared with ۳.۲ years for those anaplastic oligodendrogliomas. The ten patients who nderwent gross total resection of their timors had a better median survival time compared with the ۲۵ patients who had subtotal resection. Patients with partially resected lesions appeared to benefit from postoperative radiotherapy. The median survival period after subtotal tumor resection was better than patients without radiotherapy.

کلیدواژه ها:

Oligodendrogliomas ، Glial tumors ، combined ، Treatment Modality